Computational methods for biomechanical applications: in silico approaches for medicine

Advancements in computational methods for biomechanical applications can speed up the rate of scientific discovery in medicine and improve the effectiveness of clinical approaches. In silico analyses reduce indeed the need for experimental clinical trials, allowing to reproduce different pathophysiological scenarios in a rapid and low-cost way. In particular, computational biomechanics contributes to: (i) clarify the complex mechanobiological equilibrium that maintain the physiological behavior; (ii) identify the relationships between histological and biochemical alterations with pathologies; (iii) gain a better understanding of the etiology of diseases; (iv) support the tailoring of clinical treatments to patient-specific features.

In our Institute, we develop novel solutions for biomechanical computational challenges, accounting for the interplay between mechanical, chemical and biological mechanisms occurring in health and disease. The response of biological tissues is analyzed, together with the design and optimization of medical devices. In particular, active projects address:

  • in-stent restenosis

  • smart hydrogels for drug-delivery and bioprinting applications

  • magnesium-based foams as bioresorbable bone substitute material

  • red-Blood-Cell simulation in stenosed vessels

In Silicio Analyses