Coupling Microscale Transport and Tissue Mechanics
Modeling Strategies for Arterial Multiphysics
- verfasst von
- M. Marino, G. Pontrelli, G. Vairo, P. Wriggers
- Abstract
Arterial physiopathological behavior involves multiphysics mechanisms, as the result of the complex interplay between microscale transport phenomena and mechanical equilibrium. This chapter draws a modeling strategy for coupling macroscopic mechanics and molecular diffusive/reactive mechanisms via biochemically-motivated tissue remodeling laws.Results have been obtained by addressing the effects of extracellular matrix remodeling driven by matrix metalloproteinases, transforming growth factor-beta and interleukines on the compliance of an axisymmetric arterial segment. Remarkably, obtained results show that the present approach is able to capture arterial dilation as a consequence of alterations in the cellular activity, as well as to incorporate the protective role of pharmacological treatments.
- Organisationseinheit(en)
-
Institut für Kontinuumsmechanik
- Externe Organisation(en)
-
Consiglio Nazionale delle Ricerche (CNR)
Università degli studi di Roma Tor Vergata
- Typ
- Beitrag in Buch/Sammelwerk
- Seiten
- 77-112
- Anzahl der Seiten
- 36
- Publikationsdatum
- 06.01.2017
- Publikationsstatus
- Veröffentlicht
- Peer-reviewed
- Ja
- ASJC Scopus Sachgebiete
- Agrar- und Biowissenschaften (insg.), Biochemie, Genetik und Molekularbiologie (insg.)
- Elektronische Version(en)
-
https://doi.org/10.1016/b978-0-12-804595-4.00004-3 (Zugang:
Geschlossen)
