Comparison of degradation behaviour and osseointegration of the two magnesium scaffolds, LAE442 and La2, in vivo

verfasst von: N. Kleer, Stefan Michael Julmi, Ann-Kathrin Sigrid Elisabeth Gartzke, J. Augustin, F. Feichtner, Anja Christina Waselau, Christian Klose, Hans Jürgen Maier, Peter Wriggers, Andrea Meyer-Lindenberg
Abstract: Porous magnesium implants have been investigated for some time for their orthopaedic applicability as resorbable bone substitutes. The objective of this study was to evaluate the in vivo degradation behaviour and osseointegration of open-pored scaffolds made of the two magnesium alloys, LAE442 (n = 40) and Mg-La2 (n = 40). Cylindrical magnesium scaffolds (diameter 4 mm, length 5 mm) with defined interconnecting pore structure were produced by investment casting and coated with MgF₂. Commercially available porous ß-tricalcium phosphate scaffolds (TCP, n = 40) of the same dimensions served as control. The scaffolds were inserted in the cancellous part of the greater trochanter of both femurs in rabbits and evaluated over a period of 36 weeks using regular clinical, radiological and in vivo µCT examinations. No clinical adverse reactions were observed in any of the scaffolds. The X-ray and µCT image evaluation of La2 showed fast and inhomogeneous degradation behaviour with increased gas formation and a rapid loss of scaffold structure and shape from week 12 on. In comparison, the LAE442 scaffolds showed a slow, homogeneous degradation with low but continuous gas production over the entire study period. Furthermore, LAE442 scaffolds showed comparatively better osseointegration with more trabecular contacts than La2 scaffolds and retained their original scaffold structure. Although the TCP control group demonstrated the best osseointegration, it showed overly-rapid degradation. Based on the results of this study, the LAE422 scaffolds have promising properties for further investigations in weight-bearing bone defects.
Organisationseinheit(en): Institut für Werkstoffkunde
Institut für Kontinuumsmechanik
Externe Organisation(en): Ludwig-Maximilians-Universität München (LMU)
Typ: Artikel
Journal: Acta Materialia
Band: 8
ISSN: 1359-6454
Publikationsdatum: 12.2019
Publikationsstatus: Veröffentlicht
Peer-reviewed: Ja
ASJC Scopus Sachgebiete: Werkstoffwissenschaften (insg.)
Elektronische Version(en): https://doi.org/10.1016/j.mtla.2019.100436 (Zugang: Geschlossen)
: Details im Forschungsportal „Research@Leibniz University“

BibTeX

@article{9ddc5e8cd8514e03a6235dce21ec2806,
title = "Comparison of degradation behaviour and osseointegration of the two magnesium scaffolds, LAE442 and La2, in vivo",
abstract = "Porous magnesium implants have been investigated for some time for their orthopaedic applicability as resorbable bone substitutes. The objective of this study was to evaluate the in vivo degradation behaviour and osseointegration of open-pored scaffolds made of the two magnesium alloys, LAE442 (n = 40) and Mg-La2 (n = 40). Cylindrical magnesium scaffolds (diameter 4 mm, length 5 mm) with defined interconnecting pore structure were produced by investment casting and coated with MgF2. Commercially available porous {\ss}-tricalcium phosphate scaffolds (TCP, n = 40) of the same dimensions served as control. The scaffolds were inserted in the cancellous part of the greater trochanter of both femurs in rabbits and evaluated over a period of 36 weeks using regular clinical, radiological and in vivo µCT examinations. No clinical adverse reactions were observed in any of the scaffolds. The X-ray and µCT image evaluation of La2 showed fast and inhomogeneous degradation behaviour with increased gas formation and a rapid loss of scaffold structure and shape from week 12 on. In comparison, the LAE442 scaffolds showed a slow, homogeneous degradation with low but continuous gas production over the entire study period. Furthermore, LAE442 scaffolds showed comparatively better osseointegration with more trabecular contacts than La2 scaffolds and retained their original scaffold structure. Although the TCP control group demonstrated the best osseointegration, it showed overly-rapid degradation. Based on the results of this study, the LAE422 scaffolds have promising properties for further investigations in weight-bearing bone defects.",
keywords = "Biodegradable implants, Magnesium alloy, Micro-tomography, Osseointegration, Porous scaffolds",
author = "N. Kleer and Julmi, {Stefan Michael} and Gartzke, {Ann-Kathrin Sigrid Elisabeth} and J. Augustin and F. Feichtner and Waselau, {Anja Christina} and Christian Klose and Maier, {Hans J{\"u}rgen} and Peter Wriggers and Andrea Meyer-Lindenberg",
note = "Funding information: This research was funded by the German Research Foundation (DFG) within the project “Interfacial effects and integration behaviour of magnesium-based sponges as bioresorbable bone substitute material” (Grant No. 271761343). The authors gratefully appreciate the financial support. Moreover, the authors thank Lisa Wurm and Beatrix Limmer for excellent technical support.",
year = "2019",
month = dec,
doi = "10.1016/j.mtla.2019.100436",
language = "English",
volume = "8",
journal = "Acta Materialia",
issn = "1359-6454",
publisher = "Elsevier Ltd.",
}