Coupling Microscale Transport and Tissue Mechanics

Modeling Strategies for Arterial Multiphysics

authored by
M. Marino, G. Pontrelli, G. Vairo, P. Wriggers
Abstract

Arterial physiopathological behavior involves multiphysics mechanisms, as the result of the complex interplay between microscale transport phenomena and mechanical equilibrium. This chapter draws a modeling strategy for coupling macroscopic mechanics and molecular diffusive/reactive mechanisms via biochemically-motivated tissue remodeling laws.Results have been obtained by addressing the effects of extracellular matrix remodeling driven by matrix metalloproteinases, transforming growth factor-beta and interleukines on the compliance of an axisymmetric arterial segment. Remarkably, obtained results show that the present approach is able to capture arterial dilation as a consequence of alterations in the cellular activity, as well as to incorporate the protective role of pharmacological treatments.

Organisation(s)
Institute of Continuum Mechanics
External Organisation(s)
National Research Council Italy (CNR)
Tor Vergata University of Rome
Type
Contribution to book/anthology
Pages
77-112
No. of pages
36
Publication date
06.01.2017
Publication status
Published
Peer reviewed
Yes
ASJC Scopus subject areas
Agricultural and Biological Sciences(all), Biochemistry, Genetics and Molecular Biology(all)
Electronic version(s)
https://doi.org/10.1016/b978-0-12-804595-4.00004-3 (Access: Closed)
 

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