Investigation of degraded bone substitutes made of magnesium alloy using scanning electron microscope and nanoindentation

authored by: Ann Kathrin Gartzke, Stefan Julmi, Christian Klose, Silke Besdo, Anja Christina Waselau, Andrea Meyer-Lindenberg, Hans-Jürgen Maier, Peter Wriggers
Abstract: Degradable bone substitutes made of magnesium alloys are an alternative to biological bone grafts. The main advantage is that they can be manufactured location- and patient-specific. To develop and scale appropriate implants using computational models, knowledge about the mechanical properties and especially the change in the properties during the degradation process is essential. Therefore, degraded open-pored implants were investigated using scanning electron microscope and nanoindentation to find their material composition and mechanical properties. Using both techniques the correlation of the material composition and the average modulus was determined. It could be shown that the average modulus of the degradation layer is distinctly lower than that of the base material. The local average modulus of degrading implant highly depends on the magnesium concentration and the accumulation of elements from the environment. A decrease in magnesium concentration leads to a decrease in the average modulus. Thus, the degrading implant had a lower stiffness than the initial structure.
Organisation(s): Institute of Continuum Mechanics
Institute of Materials Science
External Organisation(s): Ludwig-Maximilians-Universität München (LMU)
Type: Article
Journal: Journal of the Mechanical Behavior of Biomedical Materials
Volume: 109
ISSN: 1751-6161
Publication date: 09.2020
Publication status: Published
Peer reviewed: Yes
ASJC Scopus subject areas: Biomaterials, Biomedical Engineering, Mechanics of Materials
Electronic version(s): https://doi.org/10.1016/j.jmbbm.2020.103825 (Access: Closed)
: Details in the research portal "Research@Leibniz University"

BibTeX

@article{21f61498a7c14ae6a1112849781ff861,
title = "Investigation of degraded bone substitutes made of magnesium alloy using scanning electron microscope and nanoindentation",
abstract = "Degradable bone substitutes made of magnesium alloys are an alternative to biological bone grafts. The main advantage is that they can be manufactured location- and patient-specific. To develop and scale appropriate implants using computational models, knowledge about the mechanical properties and especially the change in the properties during the degradation process is essential. Therefore, degraded open-pored implants were investigated using scanning electron microscope and nanoindentation to find their material composition and mechanical properties. Using both techniques the correlation of the material composition and the average modulus was determined. It could be shown that the average modulus of the degradation layer is distinctly lower than that of the base material. The local average modulus of degrading implant highly depends on the magnesium concentration and the accumulation of elements from the environment. A decrease in magnesium concentration leads to a decrease in the average modulus. Thus, the degrading implant had a lower stiffness than the initial structure.",
keywords = "Bone substitute material, Degradation, In-vitro, In-vivo, Line-scan, Magnesium, Nanoindentation, Rabbit, Scanning electron microscope",
author = "Gartzke, {Ann Kathrin} and Stefan Julmi and Christian Klose and Silke Besdo and Waselau, {Anja Christina} and Andrea Meyer-Lindenberg and Hans-J{\"u}rgen Maier and Peter Wriggers",
note = "Funding information: This research is supported by the German Research Foundation (DFG) within the project Interfacial effects and ingrowing behaviour of magnesium-based foams as bioresorbable bone substitute material” (grant no. 271761343 ). The authors gratefully acknowledge the support.",
year = "2020",
month = sep,
doi = "10.1016/j.jmbbm.2020.103825",
language = "English",
volume = "109",
journal = "Journal of the Mechanical Behavior of Biomedical Materials",
issn = "1751-6161",
publisher = "Elsevier BV",
}