Mechano-chemo-biological computational models for arteries in health, disease and healing

From tissue remodelling to drug-eluting devices

authored by

Michele Marino, Giuseppe Vairo, Peter Wriggers

Abstract

This review aims to highlight urgent priorities for the computational biomechanics community in the framework of mechano-chemo-biological models. Recent approaches, promising directions and open challenges on the computational modelling of arterial tissues in health and disease are introduced and investigated, together with in silico approaches for the analysis of drug-eluting stents that promote pharmacological-induced healing. The paper addresses a number of chemo-biological phenomena that are generally neglected in biomechanical engineering models but are most likely instrumental for the onset and the progression of arterial diseases. An interdisciplinary effort is thus encouraged for providing the tools for an effective in silico insight into medical problems. An integrated mechano-chemo-biological perspective is believed to be a fundamental missing piece for crossing the bridge between computational engineering and life sciences, and for bringing computational biome-chanics into medical research and clinical practice.

Organisation(s)

Institute of Continuum Mechanics

External Organisation(s)

Tor Vergata University of Rome

Type

Review article

Journal

Current Pharmaceutical Design

Volume

27

Pages

1904-1917

No. of pages

14

ISSN

1381-6128

Publication date

05.2021

Publication status

Published

Peer reviewed

Yes

ASJC Scopus subject areas

Pharmacology, Drug Discovery

Electronic version(s)

https://doi.org/10.2174/1381612826666200728145752 (Access: Closed)